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Price of Midodrine
Midodrine hcl 2.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Midodrine volume of distribution
What is Midodrine
An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. (PubChem)
Midodrine mechanism of action
Midodrine forms an active metabolite, desglymidodrine, that is an alpha sub 1 /sub -agonist, and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. Desglymidodrine does not stimulate cardiac beta-adrenergic receptors.
Dosage forms of Midodrine
Shire Pharma Canada Ulc
Humans and other mammals
Indication of Midodrine
For the treatment of symptomatic orthostatic hypotension (OH).
Toxicity of Midodrine
Symptoms of overdose could include hypertension, piloerection (goosebumps), a sensation of coldness and urinary retention. The single doses that would be associated with symptoms of overdosage or would be potentially life- threatening are unknown. The oral LD sub 50 /sub is approximately 30 to 50 mg/kg in rats, 675 mg/kg in mice, and 125 to 160 mg/kg in dogs. Desglymidodrine is dialyzable.
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