Save up -80% on Mifepristone

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Mifepristone

Mifeprex 200 mg tablet

$90.0

tablet

* price without discount in nearest pharmacy. Price may vary.

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Mifepristone volume of distribution

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What is Mifepristone

A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex (mifepristone 200mg) and Korlym (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).

Mifepristone mechanism of action

The anti-progestational activity of mifepristone results from competitive interaction with progesterone at progesterone-receptor sites. Based on studies with various oral doses in several animal species (mouse, rat, rabbit and monkey), the compound inhibits the activity of endogenous or exogenous progesterone. The termination of pregnancy results. In the treatment of Cushing’s syndrome, Mifepristone blocks the binding of cortisol to its receptor. It does not decrease cortisol production but reduces the effects of excess cortisol, such as high blood sugar levels.

Dosage forms of Mifepristone

FormRouteStrength
Tabletoral300 mg/1
Kit; tabletbuccal; oral
Prescription Generics

false

International Brands

Korlym

Synonyms

11-(4-DIMETHYLAMINO-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodec ahydro-cyclopenta(a)phenanthren-3-one Corlux

Manufacturers

Corcept Therapeutics Inc

CAS number

84371-65-3

UNII

320T6RNW1F

State

solid

Affected organisms

Humans and other mammals

Indication of Mifepristone

For the medical termination of intrauterine pregnancy through 49 days’ pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing’s syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.

Toxicity of Mifepristone

Nearly all of the women who receive mifepristone will report adverse reactions, and many can be expected to report more than one such reaction. About 90% of patients report adverse reactions following administration of misoprostol on day three of the treatment procedure. Side effects include more heavy bleeding than a heavy menstrual period, abdominal pain, uterine cramping, nausea, vomiting, and diarrhea.

RX24 Drugs Disclaimer: before buying a Mifepristone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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