Save up -80% on Milnacipran

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Milnacipran

Savella 100 mg tablet

$2.13

tablet

* price without discount in nearest pharmacy. Price may vary.

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Milnacipran volume of distribution

400 L, following a single IV dose to a healthy subject.

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What is Milnacipran

Milnacipran is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. It more potently inhibits norepinephrine uptake than serotonin. It is provided as a racemic mixture. FDA approved in January 2009.

Milnacipran mechanism of action

Milnacipran inhibits norepinephrine and serotonin reuptake in a 3:1 ratio, in practical use this means a balanced (equal) action upon both transmitters. The serotonin reuptake inhibition is likely to improve depression, while the norepinephrine reuptake inihibition probably improves chronic pain. Milnacipran exerts no significant actions on postynaptic H1, alpha-1, D1, D2, and muscarinic receptors, as well as on benzodiazepine/opiate binding sites.[Wikipedia]

Dosage forms of Milnacipran

DrugDosageQuantityPrice
Milnacipran50mg100 Capsule$148.00
Savella50mg56 Capsule$106.00
Prescription Generics

true

International Brands

Milnacipran Hydrochloride

Synonyms

(-)-milnacipran Midalcipran

Manufacturers

Ranbaxy Pharmaceuticals Inc.

CAS number

92623-85-3

UNII

G56VK1HF36

State

solid

Affected organisms

Humans and other mammals

Indication of Milnacipran

Milnacipran is used to treat moderate to severe clinical depression but this indication is not yet FDA-approved in the USA. Milnacipran is labelled for the treatment of fibromyalgia pain.

Toxicity of Milnacipran

LD50, oral, rat: 213 mg/kg. The most frequently occurring adverse reactions ( 5% and greater than placebo) were nausea, headache, constipation, dizziness, insomnia, hot flush, hyperhidrosis, vomiting, palpitations, heart rate increased, dry mouth, and hypertension.

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