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Price of Milrinone
Milrinone lact 10 mg/10 ml vial
* price without discount in nearest pharmacy. Price may vary.
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Milrinone volume of distribution
* 0.38 liters/kg (intravenous injections of 12.5 mcg/kg to 125 mcg/kg to congestive heart failure patients)
* 0.45 liters/kg (intravenous infusions of 0.20 mcg/kg/min to 0.70 mcg/kg/min to congestive heart failure patients)
What is Milrinone
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone. (PubChem)
Milrinone mechanism of action
Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
Dosage forms of Milrinone
|Injection, solution||intravenous||1 mg/mL|
|Injection, solution||intravenous||10 mg/10mL|
Humans and other mammals
Indication of Milrinone
Indicated for the treatment of congestive heart failure.
Toxicity of Milrinone
LD sub 50 /sub = 0.3 mg/L in rats
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