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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Solodyn

$200.4530 tablets/90mg
Price with discount in nearest pharmacy. Price may vary.

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Minocycline volume of distribution

The total body clearance was 0.16+/-0.04 L/h/kg, and the volume of distribution at steady state was 1.53+/-0.09 L/kg. The percentage of plasma protein binding was 68.1+/-2.6%. Plasma concentration of free minocycline was 0.12 microg/mL at 12 hours.

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2018 Statistics

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What is Minocycline

A tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections.

Minocycline mechanism of action

Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.

Dosage forms of Minocycline

Capsuleoral100 mg
Capsuleoral50 mg
Powderoral1 mg/1

Prescription Generics


International Brands

Apo-minocycline Cap 100mg


(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 7-Dimethylamino-6-demethyl-6-deoxytetracycline


Apotex Inc

CAS number






Affected organisms

Enteric bacteria and other eubacteria

Indication of Minocycline

For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by i Streptococcus pneumoniae and for the treatment of asymptomatic carriers of i Neisseria meningitidis.

Toxicity of Minocycline

Minocycline has been observed to cause a dark discoloration of the thyroid in experimental animals (rats, minipigs, dogs and monkeys). In the rat, chronic treatment with minocycline has resulted in goiter accompanied by elevated radioactive iodine uptake and evidence of thyroid tumor production. Minocycline has also been found to produce thyroid hyperplasia in rats and dogs. LD sub 50 /sub =2380 mg/kg (rat, oral), LD sub 50 /sub =3600 mg/kg (mouse, oral)

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What is Solodyn?

Solodyn is a tetracycline antibiotic, supplied as an extended release tablet. This is a prescription medicine used to treat acne and red bumps (non-inflammatory lesions) that occur in moderate to severe acne in people 12 years and older. Solodyn is not effective for acne that is not reddish (this means that acne is not inflammatory).

Do not use Solodyn if you are pregnant. This may harm the unborn child or cause permanent discoloration of the teeth later in life.

Solodyn can make birth control pills less effective. Ask your doctor about using a non-hormonal method of birth control (for example, a condom, diaphragm, spermicide) to prevent pregnancy when using Solodyn.

Minocycline enters breast milk and can affect the development of bones and teeth in an infant. Do not take Solodyn without telling your doctor if you are breastfeeding. Children should not take this medication. Minocycline may cause permanent yellowing or gray hair of children under the age of 8 years.

Avoid exposure to sunlight or tanning beds. Solodyn can make you sunburn easier. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not take iron supplements, multivitamins, calcium supplements, antacids or laxatives for 2 hours before or after taking Solodyn. These products may make this medicine less effective. Discard unused medication after the expiration date of the label. The use of expired minocycline can cause kidney damage.