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Price of Minocycline
Apo-Minocycline 100 mg Capsule
* price without discount in nearest pharmacy. Price may vary.
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Minocycline volume of distribution
What is Minocycline
A tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. (PubChem)
Minocycline mechanism of action
Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
Dosage forms of Minocycline
Apo-minocycline Cap 100mg
Enteric bacteria and other eubacteria
Indication of Minocycline
For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by i Streptococcus pneumoniae /i and for the treatment of asymptomatic carriers of i Neisseria meningitidis /i .
Toxicity of Minocycline
Minocycline has been observed to cause a dark discoloration of the thyroid in experimental animals (rats, minipigs, dogs and monkeys). In the rat, chronic treatment with minocycline has resulted in goiter accompanied by elevated radioactive iodine uptake and evidence of thyroid tumor production. Minocycline has also been found to produce thyroid hyperplasia in rats and dogs. LD sub 50 /sub =2380 mg/kg (rat, oral), LD sub 50 /sub =3600 mg/kg (mouse, oral)
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