Save up -80% on Mipomersen
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Kynamro
|$27,533||4 kits (1 syringe) 200mg/ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Mipomersen coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Mipomersen every time. What are you waiting for? Claim your prescription drug card now!
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Mipomersen volume of distribution
The volume of distribution for mipomersen was not quantified.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Mipomersen
Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications. It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black box warning of hepatoxicity. Specifically, elevations in the liver enzymes, i.e. transaminases, and in liver fat (hepatic steatosis) have been reported. Due to this serious risk of liver toxicity, mipomersen sodium is only available to patients under the restricted program called Kynamro Risk Evaluation and Mitigation Strategy program.
Mipomersen mechanism of action
Mipomersen binds to the mRNA that codes for apoB-100. This binding leads to double-stranded RNA, which is degraded by RNase H and prevents translation of the mRNA to form the apo B-100 protein.
Dosage forms of Mipomersen
|Injection, solution||subcutaneous||200 mg/mL|
Kastle Therapeutics Llc
Humans and other mammals
Indication of Mipomersen
Used in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications.
Toxicity of Mipomersen
The FDA label includes a black box warning of mipomersem induced hepatoxicity. Other less serious adverse effects include nausea, headache, fatigue, local injection site reactions, and flu-like symptoms.
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