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Price of Mirtazapine
Mirtazapine 7.5 mg tablet
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Mirtazapine volume of distribution
What is Mirtazapine
Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. Mirtazapine has a tetracyclic chemical structure and is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is the only tetracyclic antidepressant that has been approved by the Food and Drug Administration to treat depression. (Wikipedia)
Mirtazapine mechanism of action
Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE release. Blockade of heteroreceptors, alpha(2)-receptors contained in serotenergic neurons, enhances the release of 5-HT, increasing the interactions between 5-HT and 5-HT sub 1 /sub receptors and contributing to the anxiolytic effects of mirtazapine. Mirtazapine also acts as a weak antagonist at 5-HT sub 1 /sub receptors and as a potent antagonist at 5-HT sub 2 /sub (particularly subtypes 2A and 2C) and 5-HT sub 3 /sub receptors. Blockade of these receptors may explain the lower incidence of adverse effects such as anxiety, insomnia, and nausea. Mirtazapine also exhibits significant antagonism at H1-receptors, resulting in sedation. Mirtazapine has no effects on the reuptake of either NE or 5-HT and has only minimal activity at dopaminergic and muscarinic receptors.
Dosage forms of Mirtazapine
Humans and other mammals
Indication of Mirtazapine
For the treatment of major depressive disorder.
Toxicity of Mirtazapine
Symptoms of overdose include disorientation, drowsiness, impaired memory, and tachycardia. LD50 is 600-720mg/kg (oral, mice) and 320-490mg/kg (oral, rat) (PMID: 10333982)
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