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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Mirtazapine

Mirtazapine 7.5 mg tablet



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Mirtazapine volume of distribution

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What is Mirtazapine

Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. Mirtazapine has a tetracyclic chemical structure and is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is the only tetracyclic antidepressant that has been approved by the Food and Drug Administration to treat depression. (Wikipedia)

Mirtazapine mechanism of action

Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE release. Blockade of heteroreceptors, alpha(2)-receptors contained in serotenergic neurons, enhances the release of 5-HT, increasing the interactions between 5-HT and 5-HT sub 1 /sub receptors and contributing to the anxiolytic effects of mirtazapine. Mirtazapine also acts as a weak antagonist at 5-HT sub 1 /sub receptors and as a potent antagonist at 5-HT sub 2 /sub (particularly subtypes 2A and 2C) and 5-HT sub 3 /sub receptors. Blockade of these receptors may explain the lower incidence of adverse effects such as anxiety, insomnia, and nausea. Mirtazapine also exhibits significant antagonism at H1-receptors, resulting in sedation. Mirtazapine has no effects on the reuptake of either NE or 5-HT and has only minimal activity at dopaminergic and muscarinic receptors.

Dosage forms of Mirtazapine

Tabletoral15 mg/1
Tabletoral30 mg/1
Tabletoral45 mg/1
Prescription Generics


International Brands



1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine 6-Azamianserin


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Mirtazapine

For the treatment of major depressive disorder.

Toxicity of Mirtazapine

Symptoms of overdose include disorientation, drowsiness, impaired memory, and tachycardia. LD50 is 600-720mg/kg (oral, mice) and 320-490mg/kg (oral, rat) (PMID: 10333982)

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