Save up -80% on Misoprostol

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Cytotec

$5.224 tablets/200 mcg
Price with discount in nearest pharmacy. Price may vary.

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We offer free Misoprostol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Misoprostol every time. What are you waiting for? Claim your prescription drug card now!

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Misoprostol volume of distribution

Misoprostol is rapidly absorbed following oral administration and its bioavailability exceeds 80%. Peak plasma concentrations of 2 to 4 g/L occur in 30 to 60 minutes, following an oral dose of 200 g.It is converted to the active misoprostol acid, which has a half-life of 30- 60 minutes. Its free acid form is highly protein-bound and has a volume of distribution of 14 + 0.4 litres/kg.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Misoprostol

A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.

Misoprostol mechanism of action

Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. The activity of this receptor is mediated by G proteins which normally activate adenylate cyclase. The indirect inhibition of adenylate cyclase by Misoprostol may be dependent on guanosine-5rsquo;-triphosphate (GTP). The significant cytoprotective actions of misoprostol are related to several mechanisms. These include: 1. Increased secretion of bicarbonate, 2. Considerable decrease in the volume and pepsin content of the gastric secretions, 3. It prevents harmful agents from disrupting the tight junctions between the epithelial cells which stops the subsequent back diffusion of H sup + /sup ions into the gastric mucosa, 4. Increased thickness of mucus layer, 5. Enhanced mucosal blood flow as a result of direct vasodilatation, 6. Stabilization of tissue lysozymes/vascular endothelium, 7. Improvement of mucosal regeneration capacity, and 8. Replacement of prostaglandins that have been depleted as a result of various insults to the area. Misoprostol has also been shown to increase the amplitude and frequency of uterine contractions during pregnancy via selective binding to the EP-2/EP-3 prostanoid receptors.

Dosage forms of Misoprostol

FormRouteStrength
Tablet, film coatedoral
Tabletoral
Tabletoral100 ug/1

Prescription Generics

false

International Brands

Act Diclo-miso

Synonyms

Cytotec Misoprostolum

Manufacturers

Actavis Pharma Company

CAS number

59122-46-2

UNII

0E43V0BB57

State

liquid

Affected organisms

Humans and other mammals

Indication of Misoprostol

Indicated for the treatment of ulceration (duodenal, gastric and NSAID induced) and prophylaxis for NSAID induced ulceration. Misoprostol is also indicated for other uses that are not approved in Canada, including the medical termination of an intrauterine pregnancy used alone or in combination with methotrexate,as well as the induction of labour in a selected population of pregnant women with unfavourable cervices. This indication is avoided in women with prior uterine surgery or cesarean surgery due to an increased risk of possible uterine rupture. Misoprostol is also used for the prevention or treatment of serious postpartum hemorrhage.

Toxicity of Misoprostol

Misoprostol should not be used in pregnant women or women of childbearing age. In one clinical trial, bleeding occurred in about 50% of pregnant women in the first trimester, and complete or incomplete abortion was induced in 7%. Misoprostol is classified in FDA Pregnancy Category X.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Misoprostol on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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