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Price of Mitomycin
Mitomycin 5 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Mitomycin volume of distribution
What is Mitomycin
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional alkylating agents causing cross-linking of DNA and inhibition of DNA synthesis. (PubChem)
Mitomycin mechanism of action
Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
Dosage forms of Mitomycin
|Injection, powder, lyophilized, for solution||intravenous||20 mg/40mL|
|Injection, powder, lyophilized, for solution||intravenous||20 mg/10mL|
|Injection, powder, lyophilized, for solution||intravenous||40 mg/80mL|
Accord Healthcare Inc
Humans and other mammals
Indication of Mitomycin
For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery.
Toxicity of Mitomycin
Oral, mouse: LD sub 50 /sub = 23 mg/kg; Oral, rat: LD sub 50 /sub = 30 mg/kg. Symptoms of overdose include nausea and vomiting.
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