Save up -80% on Modafinil
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Provigil
|$34.58||30 tablets/200 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Modafinil coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Modafinil every time. What are you waiting for? Claim your prescription drug card now!
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Modafinil volume of distribution
The oral clearance (CL/F) of modafinil is 50 to 60 mL/min, and the apparent volume of distribution (Vd/F) is 50 to 60 L which indicates the possibility of tissue binding. Its plasma protein binding reaches approximately 60%.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Modafinil
Modafinil is a stimulant drug marketed as a ‘wakefulness promoting agent’ and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Modafinil mechanism of action
The exact mechanism of action is unclear, although iin vitro /i studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.
Dosage forms of Modafinil
Teva Canada Limited
Humans and other mammals
Indication of Modafinil
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
Toxicity of Modafinil
Modafanil, a non-amphetamine stimulant, is used for narcolepsy, sleep apnea, and shift work sleep disorder. There is little available information on the toxicity of modafinil overdose. In this case series, clinical effects of modafinil overdoses were generally mild with predominantly tachycardia and CNS toxicity. However, clinically significant effects warranting specific therapy occurred in a minority of patients.
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