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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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Modafinil volume of distribution

The oral clearance (CL/F) of modafinil is 50 to 60 mL/min, and the apparent volume of distribution (Vd/F) is 50 to 60 L which indicates the possibility of tissue binding. Its plasma protein binding reaches approximately 60%.

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2018 Statistics

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Clients Benefit 29%

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Total savings $4,735,080

What is Modafinil

Modafinil is a stimulant drug marketed as a ‘wakefulness promoting agent’ and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.

Modafinil mechanism of action

The exact mechanism of action is unclear, although iin vitro /i studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.

Dosage forms of Modafinil

FormRouteStrength
Tabletoral100 mg
Tabletoral100 mg/1
Tabletoral200 mg/1

Prescription Generics

false

International Brands

Alertec

Synonyms

Modafinil Modafinilo

Manufacturers

Teva Canada Limited

CAS number

68693-11-8

UNII

R3UK8X3U3D

State

solid

Affected organisms

Humans and other mammals

Indication of Modafinil

To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.

Toxicity of Modafinil

RX24 Drugs Disclaimer: before buying a Modafinil on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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