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2019 Price of Asmanex

$230.941 inhaler (60 doses) 220mcg
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Mometasone volume of distribution

A large volume of distribution results in a long elimination half-life as can be seen for fluticasone propionate (t1/2 = 7–8 hours) (10, 57, 62, 64, 65). Mometasone fuorate also has a long elimination half-life after intravenous administration; it is reported to be 5.8 hours (23).

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What is Mometasone

Mometasone is a medium-potency synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Studies in asthmatic patients have demonstrated that mometasone provides a favorable ratio of topical to systemic activity due to its primary local effect along with the extensive hepatic metabolism and the lack of active metabolites. Though effective for the treatment of asthma, glucocorticoids do not affect asthma symptoms immediately. Maximum improvement in symptoms following inhaled administration of mometasone furoate may not be achieved for 1 to 2 weeks or longer after starting treatment. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Mometasone mechanism of action

Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. Inflammation is decreased by diminishing the release of leukocytic acid hydrolases, prevention of macrophage accumulation at inflamed sites, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase Asub2/sub inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Mometasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone.

Dosage forms of Mometasone

FormRouteStrength
Inhalantrespiratory (inhalation)110 ug/1
Inhalantrespiratory (inhalation)220 ug/1
Aerosolrespiratory (inhalation)100 ug/1

Prescription Generics

true

International Brands

Apo-mometasone

Synonyms

(+)-Mometasone Mometason

Manufacturers

Apotex Inc

CAS number

105102-22-5

UNII

8HR4QJ6DW8

State

solid

Affected organisms

Humans and other mammals

Indication of Mometasone

The inhaler is indicated for the maintenance treatment of asthma as prophylactic therapy. The nasal spray is indicated for the treatment of the nasal symptoms of seasonal allergic and perennial allergic rhinitis.

Toxicity of Mometasone

The potential for acute toxic effects following overdose with the mometasone inhaler is low. However, habitual overuse of the product can cause symptoms of steroid overload, including menstrual irregularities, acne, obesity, and muscle weakness. Single oral doses up to 8000micro;g have been studied on human volunteers with no adverse events reported.

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What is a Nasonex?

Nasonex is used to treat nasal symptoms of seasonal or year-round allergies, including congestion, sneezing, and rhinitis. Nasonex is approved for this use in adults and children who are at least 2 years old. Mometasone is a steroid. This prevents the release of substances in the body that cause inflammation.

Nasonex nasal spray is also used to prevent seasonal allergy symptoms in adults and children who are at least 12 years old. Nanosex-nasal spray is also used to treat nasal polyps only in adults.

It may take up to 2 weeks of using Nasonex Nasal Spray before your symptoms improve. For best results, continue to use the drug as directed. Talk to your doctor if your symptoms do not improve after a week of treatment.

Nasonex can reduce blood cells that help your body fight infections. Avoid being near sick people or having infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal for people who use Nasonex. Avoid contact with eyes. If this happens, rinse with water and call your doctor.

What is Asmanex?

Asmanex Twisthalers contains mometasone, a corticosteroid medication. Mometasone prevents the release of substances in the body that cause inflammation. Asmanex is used to prevent asthma. He will not treat an asthma attack that has already begun.

Do not use Asmanex for asthma that has already begun. It will not work fast enough. Use only a fast-acting inhalant.

Seek medical attention if you think any medicine for asthma is working as usual. Increased need for medication may be an early sign of serious asthma.