Save up -80% on Montelukast

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Singulair

$10.7730 tablets/10 mg
price without discount in nearest pharmacy. Price may vary.

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Montelukast volume of distribution

Montelukast sodium is more than 99% bound to plasma proteins. The steady state volume of distribution of Montelukast sodium averages 8 to 11 liters.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Montelukast

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific locus of operation, it does not interact with other allergy medications such as theophylline. Montelukast is marketed in United States and many other countries by Merck amp; Co. with the brand name Singulair. It is available as oral tablets, chewable tablets, and oral granules. In India and other countries, it is also marketed under the brand name Montair reg;, produced by Indian company Cipla.

Montelukast mechanism of action

Montelukast selectively antagonizes leukotriene D sub4 /sub (LTD sub4 /sub) at the cysteinyl leukotriene receptor, CysLT sub1 /sub, in the human airway. Montelukast inhibits the actions of LTD sub4 /sub at the CysLT sub1 /sub receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

Dosage forms of Montelukast

DrugDosageQuantityPrice
Montelukast4mg100 Chewable Tablet$44.70
Montelukast5mg90 Chewable Tablet$31.00
Montelukast10mg28 Tablet$21.30
Singulair10mg28 Tablet$35.00
Singulair10mg84 Tablet$71.95
Singulair Chewables4mg28 Tablet$32.85
Singulair Chewables5mg84 Tablet$71.00

Prescription Generics

false

International Brands

Accel-montelukast Sodium Tablets

Synonyms

(R-(e))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid 1-((((1 R)-1-(3-((1e)-2-(7-chloro-2-Quinolinyl)ethenyl) phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid

Manufacturers

Accel Pharma Inc

CAS number

158966-92-8

UNII

MHM278SD3E

State

solid

Affected organisms

Humans and other mammals

Indication of Montelukast

For the treatment of asthma

Toxicity of Montelukast

Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Montelukast on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Singulair?

Singular selectively inhibits the leukotriene receptors of the epithelium of the bronchopulmonary tissue, making them immune to the action of cysteinyl leukotrienes. Singular prevents bronchospasm, sputum production, increased vascular permeability and an increase in the number of eosinophils. This is due to the fact that cysteinyl leukotrienes are pro-inflammatory mediators. When they bind to receptors, symptoms of asthma and allergic rhinitis appear.

By locking the receptors, the Singular causes bronchial relaxation for 2 hours after ingestion, reduces the content of intracellular and extracellular factors of inflammation in the airways, reduces the reactivity of the bronchi. This he suppresses bronchospasm of various stages (early and late), significantly reduces the concentration of eosinophils.