Save up -80% on Morphine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Kadian
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Kadian coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Morphine every time. What are you waiting for? Claim your prescription drug card now!
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Morphine volume of distribution
After absorption, M is rapidly and widely distributed and crosses the blood-brain barrier. With therapeutic doses, plasma protein binding is only 20-35%, and the volume of distribution is 1-6 L/kg. The primary site of M metabolism is the liver, and the dose should be reduced in patients with liver disease.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Morphine
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Morphine mechanism of action
The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. Morphine first acts on the mu-opioid receptors. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. It has been shown that morphine binds to and inhibits GABA inhibitory interneurons. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.
Dosage forms of Morphine
|Capsule, coated, extended release||oral||60 mg/1|
|Capsule, extended release||oral||120 mg/1|
|Capsule, extended release||oral||45 mg/1|
Lake Erie Medical DBA Quality Care Products LLC
Humans and other mammals
Indication of Morphine
For the relief and treatment of severe pain.
Toxicity of Morphine
LD sub 50 /sub = 461 mg/kg (rat, oral), 600 mg/kg (mouse, oral). Human lethal dose by ingestion is 120-250 mg of morphine sulfate. Symptoms of overdose include cold, clammy skin, flaccid muscles, fluid in the lungs, lowered blood pressure, “pinpoint” or dilated pupils, sleepiness leading to stupor and coma, slowed breathing, and slow pulse rate.
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