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Price of Mupirocin
Mupirocin 2% ointment
* price without discount in nearest pharmacy. Price may vary.
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Mupirocin volume of distribution
What is Mupirocin
Mupirocin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations.
Mupirocin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.
Mupirocin mechanism of action
Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Prevention of this enzymes from functioning properly results in the inhibition of bacterial protein and RNA synthesis.
Dosage forms of Mupirocin
9-((E)-4-((2S,3R,4R,5S)-3,4-dihydroxy-5-(((2S,3S)-3- ((2S,3S)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl) oxan-2-yl)-3-methylbut-2-enoyl)oxynonanoic acid
Glaxosmithkline Consumer Healthcare Inc.
Enteric bacteria and other eubacteria
Indication of Mupirocin
For the treatment of iStaphylococci /i nasal carriers.
Toxicity of Mupirocin
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