Save up -80% on Mycophenolate mofetil
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2018 Price of Mycophenolate mofetil
Mycophenolate Mofetil 250 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Mycophenolate mofetil volume of distribution
* 3.6 1.5 L/kg (intravenous, healthy subjects, MPA) * 4 1.2 L/kg (oral administration, healthy subjects, MPA)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Mycophenolate mofetil mechanism of action
Mycophenolate mofetil is hydrolyzed to form mycophenolic acid (MPA), which is the active metabolite. MPA is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, MPA has potent cytostatic effects on lymphocytes. MPA inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of MPA on lymphocytes. MPA also suppresses antibody formation by B-lymphocytes. MPA prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection. Mycophenolate mofetil did not inhibit early events in the activation of human peripheral blood mononuclear cells, such as the production of interleukin-1 (IL-1) and interleukin-2 (IL-2), but did block the coupling of these events to DNA synthesis and proliferation.
Dosage forms of Mycophenolate mofetil
|Capsule, hard||Oral use||250 mg|
Accel-mycophenolate Mofetil Capsules
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate Cellcept
Accel Pharma Inc
Humans and other mammals
Indication of Mycophenolate mofetil
For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. Mycophenolate mofetil should be used concomitantly with cyclosporine and corticosteroids.
Toxicity of Mycophenolate mofetil
Oral (LD50): Acute: 352 mg/kg (Rat), 1000 mg/kg (Mouse), and gt;6000 mg/kg (Rabbit). Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.
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