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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Cellcept

$46.13120 tablets/500 mg
price without discount in nearest pharmacy. Price may vary.

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Mycophenolate mofetil volume of distribution

* 3.6 1.5 L/kg (intravenous, healthy subjects, MPA) * 4 1.2 L/kg (oral administration, healthy subjects, MPA)

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What is Mycophenolate mofetil

Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressive agent, inosine monophosphate dehydrogenase (IMPDH) inhibitor.

Mycophenolate mofetil mechanism of action

Mycophenolate mofetil is hydrolyzed to form mycophenolic acid (MPA), which is the active metabolite. MPA is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, MPA has potent cytostatic effects on lymphocytes. MPA inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of MPA on lymphocytes. MPA also suppresses antibody formation by B-lymphocytes. MPA prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection. Mycophenolate mofetil did not inhibit early events in the activation of human peripheral blood mononuclear cells, such as the production of interleukin-1 (IL-1) and interleukin-2 (IL-2), but did block the coupling of these events to DNA synthesis and proliferation.

Dosage forms of Mycophenolate mofetil

FormRouteStrength
Capsuleoral250 mg/1
Capsuleoral250 mg
Capsule, hardOral use250 mg

Prescription Generics

false

International Brands

Accel-mycophenolate Mofetil Capsules

Synonyms

2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate Cellcept

Manufacturers

Accel Pharma Inc

CAS number

128794-94-5

UNII

9242ECW6R0

State

solid

Affected organisms

Humans and other mammals

Indication of Mycophenolate mofetil

For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. Mycophenolate mofetil should be used concomitantly with cyclosporine and corticosteroids.

Toxicity of Mycophenolate mofetil

Oral (LD50): Acute: 352 mg/kg (Rat), 1000 mg/kg (Mouse), and gt;6000 mg/kg (Rabbit). Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.

RX24 Drugs Disclaimer: before buying a Mycophenolate mofetil on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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