Save up -80% on Mycophenolic acid
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2018 Price of Mycophenolic acid
Myfortic 180 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Mycophenolic acid volume of distribution
* 54 25 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Mycophenolic acid
Mycophenolic acid is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase).
Mycophenolic acid mechanism of action
Mycophenolic acid is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, mycophenolic acid has potent cytostatic effects on lymphocytes. Mycophenolic acid inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of mycophenolic acid on lymphocytes. Mycophenolic acid also suppresses antibody formation by B-lymphocytes. Mycophenolic acid prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection.
Dosage forms of Mycophenolic acid
|Tablet, delayed release||oral||180 mg/1|
|Tablet, delayed release||oral||360 mg/1|
|Tablet (enteric-coated)||oral||180 mg|
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid Acide mycophenolique
Humans and other mammals
Toxicity of Mycophenolic acid
Oral (LD50): Acute: 352 mg/kg (Rat), 1000 mg/kg (Mouse), and gt;6000 mg/kg (Rabbit). Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.
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