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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Mycophenolic acid

Myfortic 180 mg tablet

$3.85

tablet

* price without discount in nearest pharmacy. Price may vary.

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Mycophenolic acid volume of distribution

* 54 25 L

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What is Mycophenolic acid

Mycophenolic acid is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase).

Mycophenolic acid mechanism of action

Mycophenolic acid is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, mycophenolic acid has potent cytostatic effects on lymphocytes. Mycophenolic acid inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of mycophenolic acid on lymphocytes. Mycophenolic acid also suppresses antibody formation by B-lymphocytes. Mycophenolic acid prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection.

Dosage forms of Mycophenolic acid

FormRouteStrength
Tablet, delayed releaseoral180 mg/1
Tablet, delayed releaseoral360 mg/1
Tablet (enteric-coated)oral180 mg
Prescription Generics

true

International Brands

Apo-mycophenolic Acid

Synonyms

(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid Acide mycophenolique

Manufacturers

Apotex Inc

CAS number

24280-93-1

UNII

HU9DX48N0T

State

solid

Affected organisms

Humans and other mammals

Indication of Mycophenolic acid

For the prophylaxis of organ rejection in patients receiving allogeneic renal transplants, administered in combination with cyclosporine and corticosteroids.

Toxicity of Mycophenolic acid

Oral (LD50): Acute: 352 mg/kg (Rat), 1000 mg/kg (Mouse), and gt;6000 mg/kg (Rabbit). Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.

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