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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Relafen

$18.3260 tablets/500 mg
price without discount in nearest pharmacy. Price may vary.

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Nabumetone volume of distribution

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the 2,6-disubstituted naphthyl-alkanone class. Nabumetone is metabolised to an active metabolite 6-methoxy-2-napthylacetic acid (6-MNA) which is a relatively selective cyclo-oxygenase-2 inhibitor that has anti-inflammatory and analgesic properties. Nabumetone and its metabolites bind extensively to plasma albumin. Nabumetone is eliminated following biotransformation to 6-MNA, which does not undergo enterohepatic circulation and the respective glucoroconjugated metabolites are excreted in urine. Substantial concentrations of 6-MNA are attained in synovial fluid, which is he proposed site of action in chronic inflammatory arthropathies. A smaller area under the plasma concentration-time curve (AUC) is evident at steady state as compared with a single dose; this is possibly due to an increase in the volume of distribution and saturation of protein binding.

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Nabumetone

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid family (which includes diclofenac). Marketed under the brand name Relafen, it has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAIDs.

Nabumetone mechanism of action

The parent compound is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis, most likely through binding to the COX-2 and COX-1 receptors.

Dosage forms of Nabumetone

FormRouteStrength
Tabletoral500 mg
Tabletoral500 mg/1
Tabletoral750 mg/1

Prescription Generics

true

International Brands

Apo-nabumetone

Synonyms

4-(6-Methoxy-2-naphthalenyl)-2-butanone 4-(6-Methoxy-2-naphthyl)-2-butanone

Manufacturers

Apotex Inc

CAS number

42924-53-8

UNII

LW0TIW155Z

State

solid

Affected organisms

Humans and other mammals

Indication of Nabumetone

For acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.

Toxicity of Nabumetone

The one overdose occurred in a 17-year-old female patient who had a history of abdominal pain and was hospitalized for increased abdominal pain following ingestion of 30 nabumetone tablets (15 grams total). Stools were negative for occult blood and there was no fall in serum hemoglobin concentration. The patient had no other symptoms.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Nabumetone on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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