Save up -80% on Naloxegol
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2018 Price of Movantik
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Naloxegol volume of distribution
968 to 2140 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Naloxegol
Naloxegol, for “PEGylated naloxol” is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non cancer pain. The advantage of naloxegol over the opioid antagonist naloxone is that its PEGylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the central nervous system through the blood-brain barrier.
Naloxegol mechanism of action
Naloxegol is an antagonist of opioid binding at the mu-opioid receptor. When administered at the recommended dose levels, naloxegol functions as a peripherally-acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids. Naloxegol has shown more than 6000 fold selectivity for the peripheral mu receptors, and its PEGylated form restricts its action only to the periphery, not affecting the pain-relieving mechanism of opioids in the central nervous system.
Dosage forms of Naloxegol
(5 ,6 )-17-Allyl-6-[(20-hydroxy-3,6,9,12,15,18-hexaoxaicos-1-yl)oxy]-4,5-epoxymorphinan-3,14-diol
Astrazeneca Canada Inc
Humans and other mammals
Indication of Naloxegol
Indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
Toxicity of Naloxegol
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