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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Movantik

$368.4530 tablets/25 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Movantik coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Naloxegol every time. What are you waiting for? Claim your prescription drug card now!

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Naloxegol volume of distribution

The mean apparent volume of distribution during the terminal phase (Vz/F) in healthy volunteers ranged from 968 to 2140 L across dosing groups and studies. Plasma protein binding of naloxegol in humans was low (~4.2 %). Naloxegol is metabolized primarily by the CYP3A enzyme system.

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Total savings $4,735,080

What is Naloxegol

Naloxegol, for “PEGylated naloxol” is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non cancer pain. The advantage of naloxegol over the opioid antagonist naloxone is that its PEGylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the central nervous system through the blood-brain barrier.

Naloxegol mechanism of action

Naloxegol is an antagonist of opioid binding at the mu-opioid receptor. When administered at the recommended dose levels, naloxegol functions as a peripherally-acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids. Naloxegol has shown more than 6000 fold selectivity for the peripheral mu receptors, and its PEGylated form restricts its action only to the periphery, not affecting the pain-relieving mechanism of opioids in the central nervous system.

Dosage forms of Naloxegol

Movantik12.5mg60 tablet$712.62
Movantik12.5mg30 tablet$360.68
Movantik25mg15 tablet$124.45
Movantik25mg28 tablet$340.13

Prescription Generics


International Brands



(5 ,6 )-17-Allyl-6-[(20-hydroxy-3,6,9,12,15,18-hexaoxaicos-1-yl)oxy]-4,5-epoxymorphinan-3,14-diol


Astrazeneca Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Naloxegol

Indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.

Toxicity of Naloxegol

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Naloxegol on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Movantik?

Movantik is a prescription drug that blocks certain effects of narcotic drugs. An opioid is sometimes called a drug. Movantik is used to treat opioid induced constipation (AEI) caused by prescribed drugs, called drugs or opiates, in adults with prolonged (chronic) pain that is not caused by cancer. Naloxegol treats constipation without diminishing the analgesic effects of the drug.

Movantik is used in people who have taken a narcotic painkiller for at least 4 weeks to treat chronic pain that is not caused by cancer.

You should not use Movantik if you have a blockage in your stomach or intestines. Tell your doctor if you have opioid withdrawal symptoms, such as anxiety, irritability, sweating, chills, yawning, stomach pain, and diarrhea. Stop using this medicine and consult a doctor immediately if you have severe stomach pain and / or diarrhea (which can lead to serious medical problems).

Many drugs can interact with naloxol, and some drugs should not be used together. Tell your doctor about all the medicines you use and those you start or stop using during your treatment with Movantik.