Save up -80% on Naloxegol

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Movantik



* price without discount in nearest pharmacy. Price may vary.

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Naloxegol volume of distribution

968 to 2140 L.

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What is Naloxegol

Naloxegol, for “PEGylated naloxol” is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non cancer pain. The advantage of naloxegol over the opioid antagonist naloxone is that its PEGylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the central nervous system through the blood-brain barrier.

Naloxegol mechanism of action

Naloxegol is an antagonist of opioid binding at the mu-opioid receptor. When administered at the recommended dose levels, naloxegol functions as a peripherally-acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids. Naloxegol has shown more than 6000 fold selectivity for the peripheral mu receptors, and its PEGylated form restricts its action only to the periphery, not affecting the pain-relieving mechanism of opioids in the central nervous system.

Dosage forms of Naloxegol

Movantik12.5mg60 tablet$712.62
Movantik12.5mg30 tablet$360.68
Movantik25mg15 tablet$124.45
Movantik25mg28 tablet$340.13
Prescription Generics


International Brands



(5 ,6 )-17-Allyl-6-[(20-hydroxy-3,6,9,12,15,18-hexaoxaicos-1-yl)oxy]-4,5-epoxymorphinan-3,14-diol


Astrazeneca Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Naloxegol

Indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.

Toxicity of Naloxegol

RX24 Drugs Disclaimer: before buying a Naloxegol on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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