Save up -80% on Naloxone
Note: this is a drug discount program, not an insurance plan.
2018 Price of Naloxone
Narcan 0.4 mg/ml ampul
* price without discount in nearest pharmacy. Price may vary.
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Naloxone volume of distribution
Following parenteral administration naloxone hydrochloride is rapidly distributed in the body. Naloxone is also very lipophillic and easily crosses the blood-brain-barrier. It can also cross the placenta.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Naloxone mechanism of action
While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.
Dosage forms of Naloxone
|Injection, solution||intramuscular; subcutaneous||.4 mg/1|
Actavis Pharma Company
Humans and other mammals
Indication of Naloxone
For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.
Toxicity of Naloxone
LD50, IV administration, mouse = 150 5 mg/kg; LD50, IV administration, rat = 109 4 mg/kg;
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