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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Naloxone

Narcan 0.4 mg/ml ampul



* price without discount in nearest pharmacy. Price may vary.

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Naloxone volume of distribution

Following parenteral administration naloxone hydrochloride is rapidly distributed in the body. Naloxone is also very lipophillic and easily crosses the blood-brain-barrier. It can also cross the placenta.

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What is Naloxone

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

Naloxone mechanism of action

While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.

Dosage forms of Naloxone

Injection, solutionintramuscular; subcutaneous.4 mg/1
Prescription Generics


International Brands

Act Buprenorphine/naloxone


1-N-Allyl-14-hydroxynordihydromorphinone 17-Allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one


Actavis Pharma Company

CAS number






Affected organisms

Humans and other mammals

Indication of Naloxone

For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.

Toxicity of Naloxone

LD50, IV administration, mouse = 150 5 mg/kg; LD50, IV administration, rat = 109 4 mg/kg;

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