Save up -80% on Naltrexone
Note: this is a drug discount program, not an insurance plan.
2018 Price of Naltrexone
Depade 50 mg tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Naltrexone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Naltrexone every time. What are you waiting for? Claim your prescription drug card now!
Naltrexone volume of distribution
* 1350 L (intravenous administration)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Naltrexone
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Naltrexone mechanism of action
Naltrexone is a pure opiate antagonist and has little or no agonist activity. The mechanism of action of naltrexone in alcoholism is not understood; however, involvement of the endogenous opioid system is suggested by preclinical data. Naltrexone is thought to act as a competitive antagonist at mc, , and receptors in the CNS, with the highest affintiy for the receptor. Naltrexone competitively binds to such receptors and may block the effects of endogenous opioids. This leads to the antagonization of most of the subjective and objective effects of opiates, including respiratory depression, miosis, euphoria, and drug craving. The major metabolite of naltrexone, 6–naltrexol, is also an opiate antagonist and may contribute to the antagonistic activity of the drug.
Dosage forms of Naltrexone
Humans and other mammals
Indication of Naltrexone
Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
Toxicity of Naltrexone
In the mouse, rat and guinea pig, the oral LD sub50 /subs were 1,100-1,550 mg/kg; 1,450 mg/kg; and 1,490 mg/kg; respectively. High doses of naltrexone (generally ge;1,000 mg/kg) produce salivation, depression/reduced activity, tremors, and convulsions.
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