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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Aleve

$7.05100 tablets/220 mg
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Naproxen volume of distribution

After oral administration of naproxen sodium tablets, peak plasma levels are attained in 1 to 2 hours. Distribution: Naproxen has a volume of distribution of 0.16 L/kg. At therapeutic levels naproxen is greater than 99% albumin-bound.

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2018 Statistics

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Total savings $4,735,080

What is Naproxen

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Naproxen mechanism of action

The mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.

Dosage forms of Naproxen

Naproxen125mg100 Tablet$37.50
Naproxen500mg30 Suppositories$58.00
Naproxen500mg60 Suppositories$101.00
Naproxen500mg90 Suppositories$144.00
Naprosyn SR750mg100 SA tablet$183.25
Naproxen Sodium275mg100 Tablet$57.00
Naprosyn EC250mg112$69.00
Naprosyn EC375mg112$87.00
Naprosyn EC500mg112$109.00
Vimovo375/20mg60 EC Tablet (Delayed Release)$112.00
Vimovo500/20mg60 EC Tablet (Delayed Release)$112.00
Anaprox275mg100 Tablet$109.00

Prescription Generics


International Brands

7 Select Naproxen Sodium


(+)-(S)-6-Methoxy-.-methyl-2-naphthaleneacetic acid (+)-(S)-Naproxen


7 Eleven

CAS number






Affected organisms

Humans and other mammals

Indication of Naproxen

For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.

Toxicity of Naproxen

ORAL (LDsub50/sub): Acute: 248 mg/kg (Rat). 360 mg/kg (Mouse). Symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting.

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