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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Natacyn

$334.281 eye dropper (15ml) 5%
price without discount in nearest pharmacy. Price may vary.

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Natamycin volume of distribution

The distribution of natamycin was studied by autoradiographic and bioautographic techniques. In the autoradiographic study, five female Wistar rats (TNO, specific pathogen-free) were each given a single dose of 50 mg/kg bw of [14C]natamycin (50 mg in 5 ml of 1% amylum) orally. In the bioautographic study, four female rats were each given a single dose of 50 mg/kg bw (70 mg in 7 ml of 1% amylum) orally. No information on the purity of the compound was provided. Before treatment, the animals were fasted for 24 h but were given a 5% glucose drinking-water solution. One animal in each group was killed by immersion in a solid CO2 and acetone mixture under mild ether anaesthesia 1, 2 (autoradiographic study only), 4, 8, and 24 h after treatment. Whole-body sections of the animals were cut in a cryostat at –20 °C.

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What is Natamycin

Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.

Natamycin mechanism of action

LIke other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.

Dosage forms of Natamycin

FormRouteStrength
Suspension/ dropsophthalmic50 mg/mL

Prescription Generics

false

International Brands

Natacyn

Synonyms

Natamicina Natamycin

Manufacturers

Alcon Laboratories, Inc.

CAS number

7681-93-8

UNII

8O0C852CPO

State

solid

Affected organisms

Various Fungus Species

Indication of Natamycin

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including iFusarium solani/i keratitis.

Toxicity of Natamycin

The available data on the acute toxicity of natamycin are summarized in Table 1. They suggest that male rats are more sensitive to the acute toxicity of orally administered natamycin than females (Levinskas et al., 1966). However, in a study by van Eken and Wubs (1976) to determine the LD50 values for natamycin and three of its potential metabolites after intraperitoneal administration to mice, females were more susceptible to the lethal effects (Table 1). The LD50 values of the metabolites of natamycin in this study were higher than that for natamycin, indicating that they are less acutely toxic than the parent compound. LD50 values of 3200, 3700, and > 4000 mg/kg were reported for aponatamycin (n = 2), mycosamine hydrochloride (n = 2), and dinatamycinolidediole (range-finding study), respectively, which are potential metabolites of natamycin.

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