Save up -80% on Nefazodone
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Serzone
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Nefazodone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Nefazodone every time. What are you waiting for? Claim your prescription drug card now!
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Nefazodone volume of distribution
Nefazodone is widely distributed in body tissues, including the central nervous system (CNS). In humans the volume of distribution of nefazodone ranges from 0.22 to 0.87 L/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nefazodone
Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury, which could lead to the need for a liver transplant, or even death. The incidence of severe liver damage is approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. (Wikipedia)
Nefazodone mechanism of action
Within the serotonergic system, nefazodone acts as an antagonist at type 2 serotonin (5-HT sub2 /sub) post-synaptic receptors and, like fluoxetine-type antidepressants, inhibits pre-synaptic serotonin (5-HT) reuptake. These mechanisms increase the amount of serotonin available to interact with 5-HT receptors. Within the noradrenergic system, nefazodone inhibits norepinephrine uptake minimally. Nefazodone also antagonizes alpha(1)-adrenergic receptors, producing sedation, muscle relaxation, and a variety of cardiovascular effects. Nefazodone’s affinity for benzodiazepine, cholinergic, dopaminergic, histaminic, and beta or alpha(2)-adrenergic receptors is not significant.
Dosage forms of Nefazodone
Linson Pharma Co.
Humans and other mammals
Indication of Nefazodone
For the treatment of depression.
Toxicity of Nefazodone
Cases of life-threatening hepatic failure have been reported in patients treated with nefazodone.
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