Save up -80% on Neostigmine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Neostigmine
Prostigmin 15 mg tablet
|price without discount in nearest pharmacy. Price may vary.|
We offer free Neostigmine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Neostigmine every time. What are you waiting for? Claim your prescription drug card now!
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Neostigmine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Neostigmine
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
Neostigmine mechanism of action
Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. The drug inhibits acetylcholinesterase which is responsible for the degredation of acetylcholine. So, with acetylcholinesterase inhibited, more acetylcholine is present By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors which are involved in muscle contraction.. It does not cross the blood-brain barrier.
Dosage forms of Neostigmine
|Injection||intramuscular; intravenous; subcutaneous||.5 mg/mL|
|Injection||intramuscular; intravenous; subcutaneous||1 mg/mL|
(m-Hydroxyphenyl)trimethylammonium dimethylcarbamate 3-Trimethylammoniumphenyl N,N-dimethylcarbamate
Eclat Pharmaceuticals, LLC
Humans and other mammals
Indication of Neostigmine
Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
Toxicity of Neostigmine
Overdosage of Neostigmine can cause cholinergic crisis, which is characterized by increasing muscle weakness, and through involvement of the muscles of respiration, may result in death. The LD 50 of neostigmine methylsulfate in mice is 0.3 -plusmn; 0.02 mg/kg intravenously, 0.54 -plusmn; 0.03 mg/kg subcutaneously, and 0.395 -plusmn; 0.025 mg/kg intramuscularly; in rats the LD 50 is 0.315 -plusmn; 0.019 mg/kg intravenously, 0.445 -plusmn; 0.032 mg/kg subcutaneously, and 0.423 -plusmn; 0.032 mg/kg intramuscularly.
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