Save up -80% on Neostigmine
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2018 Price of Neostigmine
Prostigmin 15 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Neostigmine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Neostigmine mechanism of action
Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. The drug inhibits acetylcholinesterase which is responsible for the degredation of acetylcholine. So, with acetylcholinesterase inhibited, more acetylcholine is present By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors which are involved in muscle contraction.. It does not cross the blood-brain barrier.
Dosage forms of Neostigmine
|Injection||intramuscular; intravenous; subcutaneous||.5 mg/mL|
|Injection||intramuscular; intravenous; subcutaneous||1 mg/mL|
(m-Hydroxyphenyl)trimethylammonium dimethylcarbamate 3-Trimethylammoniumphenyl N,N-dimethylcarbamate
Eclat Pharmaceuticals, LLC
Humans and other mammals
Indication of Neostigmine
Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
Toxicity of Neostigmine
Overdosage of Neostigmine can cause cholinergic crisis, which is characterized by increasing muscle weakness, and through involvement of the muscles of respiration, may result in death. The LD 50 of neostigmine methylsulfate in mice is 0.3 -plusmn; 0.02 mg/kg intravenously, 0.54 -plusmn; 0.03 mg/kg subcutaneously, and 0.395 -plusmn; 0.025 mg/kg intramuscularly; in rats the LD 50 is 0.315 -plusmn; 0.019 mg/kg intravenously, 0.445 -plusmn; 0.032 mg/kg subcutaneously, and 0.423 -plusmn; 0.032 mg/kg intramuscularly.
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