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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Neostigmine

Prostigmin 15 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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What is Neostigmine

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Neostigmine mechanism of action

Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. The drug inhibits acetylcholinesterase which is responsible for the degredation of acetylcholine. So, with acetylcholinesterase inhibited, more acetylcholine is present By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors which are involved in muscle contraction.. It does not cross the blood-brain barrier.

Dosage forms of Neostigmine

Injectionintramuscular; intravenous; subcutaneous.5 mg/mL
Injectionintramuscular; intravenous; subcutaneous1 mg/mL
Injectionintravenous.5 mg/mL
Prescription Generics


International Brands



(m-Hydroxyphenyl)trimethylammonium dimethylcarbamate 3-Trimethylammoniumphenyl N,N-dimethylcarbamate


Eclat Pharmaceuticals, LLC

CAS number






Affected organisms

Humans and other mammals

Indication of Neostigmine

Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.

Toxicity of Neostigmine

Overdosage of Neostigmine can cause cholinergic crisis, which is characterized by increasing muscle weakness, and through involvement of the muscles of respiration, may result in death. The LD 50 of neostigmine methylsulfate in mice is 0.3 -plusmn; 0.02 mg/kg intravenously, 0.54 -plusmn; 0.03 mg/kg subcutaneously, and 0.395 -plusmn; 0.025 mg/kg intramuscularly; in rats the LD 50 is 0.315 -plusmn; 0.019 mg/kg intravenously, 0.445 -plusmn; 0.032 mg/kg subcutaneously, and 0.423 -plusmn; 0.032 mg/kg intramuscularly.

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