Save up -80% on Nicardipine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Cardene
|price without discount in nearest pharmacy. Price may vary.|
We offer free Cardene coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Nicardipine every time. What are you waiting for? Claim your prescription drug card now!
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Nicardipine volume of distribution
Total plasma clearance (Cl) is 0.4 L/hr. kg, and the apparent volume of distribution (Vd) using a non-compartment model is 8.3 L/kg. The pharmacokinetics of Cardene I.V.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nicardipine
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
Nicardipine mechanism of action
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, nicardipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Dosage forms of Nicardipine
|Injection, solution||intravenous||.1 mg/mL|
Cardene 20mg Capsules
Hoffmann La Roche Limited
Humans and other mammals
Indication of Nicardipine
Used for the management of patients with chronic stable angina and for the treatment of hypertension.
Toxicity of Nicardipine
Oral LD sub50 /sub Rat = 184 mg/kg, Oral LD sub50 /sub Mouse = 322 mg/kg
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