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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Nicardipine

Cardene sr 30 mg capsule sa



* price without discount in nearest pharmacy. Price may vary.

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Nicardipine volume of distribution

* 8.3 L/kg

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What is Nicardipine

A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.

Nicardipine mechanism of action

By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, nicardipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Dosage forms of Nicardipine

Capsuleoral20 mg
Capsuleoral30 mg
Injection, solutionintravenous.1 mg/mL
Prescription Generics


International Brands

Cardene 20mg Capsules


Cardene Nicardipino


Hoffmann La Roche Limited

CAS number






Affected organisms

Humans and other mammals

Indication of Nicardipine

Used for the management of patients with chronic stable angina and for the treatment of hypertension.

Toxicity of Nicardipine

Oral LD sub50 /sub Rat = 184 mg/kg, Oral LD sub50 /sub Mouse = 322 mg/kg

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