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Price of Nicardipine
Cardene sr 30 mg capsule sa
* price without discount in nearest pharmacy. Price may vary.
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Nicardipine volume of distribution
* 8.3 L/kg
What is Nicardipine
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. (PubChem)
Nicardipine mechanism of action
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, nicardipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Dosage forms of Nicardipine
|Injection, solution||intravenous||.1 mg/mL|
Cardene 20mg Capsules
Hoffmann La Roche Limited
Humans and other mammals
Indication of Nicardipine
Used for the management of patients with chronic stable angina and for the treatment of hypertension.
Toxicity of Nicardipine
Oral LD sub50 /sub Rat = 184 mg/kg, Oral LD sub50 /sub Mouse = 322 mg/kg
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