Save up -80% on Nicotine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Nicorette
|$46.38||100 pieces/2 mg gum|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Nicotine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Nicotine every time. What are you waiting for? Claim your prescription drug card now!
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Nicotine volume of distribution
After absorption, nicotine enters the bloodstream where, at pH 7.4, it is about 69% ionized and 31% unionized. Binding to plasma proteins is less than 5% (Benowitz et al. 1982a). The drug is distributed extensively to body tissues with a steady-state volume of distribution averaging 2.6 L/Kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nicotine
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Nicotine mechanism of action
Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Nicotine also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.
Dosage forms of Nicotine
|Nicorette Inhaler||4mg||42 Inhaler||$58.00|
|Nicotine Polacrilex||2mg||120 Gum||$45.00|
|Nicotine Polacrilex||4mg||120 Gum||$45.00|
American Fare Nicotine Transdermal System
Novartis Consumer Health, Inc.
Humans and other mammals
Indication of Nicotine
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
RX24 Drugs Disclaimer: before buying a Nicotine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.
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What is Nicorette?
Nicorette contain nicotine, the main ingredient of which is contained in tobacco products. Nicorette are medical products used to help with smoking cessation in adults. Using a controlled amount of nicotine helps reduce the symptoms of nicotine withdrawal when you quit smoking.
Do not use Nicorette if you are pregnant or nursing, unless your doctor has told you so. Do not smoke or use other nicotine products (including tobacco, chewing tobacco, nicotine patches, inhaler or nasal spray) while you are using gum or Nicorette lozenges.
Ask your doctor or pharmacist before using Nicorette if you have heart disease, heart rhythm disorder, circulatory problems, high blood pressure, a history of stroke or heart attack, problems with your mouth or teeth, jaw problems that make it difficult to chew, liver disease or kidney disease, diabetes, a thyroid disorder, a stomach ulcer, asthma or another breathing disorder, an adrenal tumor, or if you are on a diet low in salt.
Keep both used and unused Nicorette rubber and lozenges out of the reach of children or pets. The amount of nicotine in a used or unused cake or a piece of tar can be fatal to a child who accidentally sucks or chews on it.