Save up -80% on Nifedipine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Procardia
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Procardia coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Nifedipine every time. What are you waiting for? Claim your prescription drug card now!
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Nifedipine volume of distribution
After oral administration of higher doses (40 mg) and after continuous infusion over 24 hours, a third phase with a half-life of about 8 hours can be seen. The apparent volume of distribution of the central compartment (Vce) is 0.294 +/- 0.1 l/kg, and the total body clearance amounts to 0.45 +/- 0.1 liter/hr.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nifedipine
Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drugs vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.
Nifedipine mechanism of action
Nifedipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. The vasodilatory effects of nifedipine result in an overall decrease in blood pressure.
Dosage forms of Nifedipine
|Nifedipine||30mg||100 Tablet ER||$69.00|
|Nifedipine||60mg||100 Tablet ER||$105.00|
|Nifedipine Xl||20mg||100 ER Tablet||$67.76|
|Nifedipine XL||60mg||84 ER Tablet||$87.00|
|Procardia XL||20mg||84 SA Tablet||$71.69|
|Procardia XL||60mg||84 SA Tablet||$125.00|
|Adalat XL||20mg||84 SA Tablet||$71.69|
|Adalat XL||30mg||100 SA Tablet||$100.00|
|Adalat XL||60mg||100 SA Tablet||$136.00|
Humans and other mammals
Indication of Nifedipine
For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud’s phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).
Toxicity of Nifedipine
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD sub50 /sub=494 mg/kg (orally in mice); LD sub50 /sub=1022 mg/kg (orally in rats)
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