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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Procardia

$88.5030 capsules/10mg
Price with discount in nearest pharmacy. Price may vary.

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Nifedipine volume of distribution

After oral administration of higher doses (40 mg) and after continuous infusion over 24 hours, a third phase with a half-life of about 8 hours can be seen. The apparent volume of distribution of the central compartment (Vce) is 0.294 +/- 0.1 l/kg, and the total body clearance amounts to 0.45 +/- 0.1 liter/hr.

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What is Nifedipine

Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drugs vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.

Nifedipine mechanism of action

Nifedipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. The vasodilatory effects of nifedipine result in an overall decrease in blood pressure.

Dosage forms of Nifedipine

Nifedipine30mg100 Tablet ER$69.00
Nifedipine60mg100 Tablet ER$105.00
Nifedipine10mg100 Capsules$55.95
Nifedipine Xl20mg100 ER Tablet$67.76
Nifedipine XL60mg84 ER Tablet$87.00
Procardia XL20mg84 SA Tablet$71.69
Procardia XL60mg84 SA Tablet$125.00
Adalat XL20mg84 SA Tablet$71.69
Adalat XL30mg100 SA Tablet$100.00
Adalat XL60mg100 SA Tablet$136.00

Prescription Generics


International Brands



4-(2′-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester Adalat


Bayer Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Nifedipine

For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud’s phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

Toxicity of Nifedipine

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD sub50 /sub=494 mg/kg (orally in mice); LD sub50 /sub=1022 mg/kg (orally in rats)

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