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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Nifedipine

Nifediac cc 30 mg tablet

$1.15

tablet

* price without discount in nearest pharmacy. Price may vary.

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Nifedipine volume of distribution

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What is Nifedipine

Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drugs vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.

Nifedipine mechanism of action

Nifedipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. The vasodilatory effects of nifedipine result in an overall decrease in blood pressure.

Dosage forms of Nifedipine

DrugDosageQuantityPrice
Nifedipine30mg100 Tablet ER$69.00
Nifedipine60mg100 Tablet ER$105.00
Nifedipine10mg100 Capsules$55.95
Nifedipine Xl20mg100 ER Tablet$67.76
Nifedipine XL60mg84 ER Tablet$87.00
Procardia XL20mg84 SA Tablet$71.69
Procardia XL60mg84 SA Tablet$125.00
Adalat XL20mg84 SA Tablet$71.69
Adalat XL30mg100 SA Tablet$100.00
Adalat XL60mg100 SA Tablet$136.00
Prescription Generics

false

International Brands

Adalat

Synonyms

4-(2′-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester Adalat

Manufacturers

Bayer Inc

CAS number

21829-25-4

UNII

I9ZF7L6G2L

State

solid

Affected organisms

Humans and other mammals

Indication of Nifedipine

For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud’s phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

Toxicity of Nifedipine

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD sub50 /sub=494 mg/kg (orally in mice); LD sub50 /sub=1022 mg/kg (orally in rats)

RX24 Drugs Disclaimer: before buying a Nifedipine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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