Save up -80% on Nilotinib
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Tasigna
|$13,921.61||4 dose packs (28 capsules)/150 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Nilotinib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Nilotinib every time. What are you waiting for? Claim your prescription drug card now!
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Nilotinib volume of distribution
The steady state volume of distribution ranged from 0.55 to 3.9 l/kg across the species tested.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nilotinib
Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). In June 2006, a Phase I clinical trial found nilotinib has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (Gleevec-reg;), another tyrosine kinase inhibitor currently used as a first-line treatment.[Wikipedia]
Nilotinib mechanism of action
Chronic myelogenous leukaemia (CML) is caused by the BCR-ABL oncogene. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. Nilotinib fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib, over-riding resistance caused by mutations. The ability of AMN107 to inhibit TEL-platelet-derived growth factor receptor-beta (TEL-PDGFRbeta), which causes chronic myelomonocytic leukaemia, and FIP1-like-1-PDGFRalpha, which causes hypereosinophilic syndrome, suggests potential use of AMN107 for myeloproliferative diseases characterised by these kinase fusions (Stover et al, 2005; Weisberg et al, 2005). AMN107 also inhibits the c-Kit receptor kinase, including the D816V-mutated variant of KIT, at pharmacologically achievable concentrations, supporting potential utility in the treatment of mastocytosis, and gastrointestinal stromal tumours (Weisberg et al, 2005; von Bubnoff et al, 2005; Gleixner et al, 2006).
Dosage forms of Nilotinib
Novartis Pharmaceuticals Canada Inc
Humans and other mammals
Indication of Nilotinib
For the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
Toxicity of Nilotinib
Overdose with nilotinib has been reported, where an unspecified number of Tasigna capsules were ingested in combination with alcohol and other drugs. Events included neutropenia, vomiting, and drowsiness.
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