Save up -80% on Nisoldipine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Sular
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Sular coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Nisoldipine every time. What are you waiting for? Claim your prescription drug card now!
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Nisoldipine volume of distribution
Volume of distribution was 4.1 ± 2.1 liter/kg and 6.4 ± 2.3 liter/kg (NS) respectively, and systemic clearance was 0.85 ± 0.31 liter/min and 0.49 ± 0.12 liter/ min, respectively (P <0.01). On oral nisoldipine systemic availability was much higher in the patient group (14.7 ± 10.1% vs 3.7 ± 2.1% (P <0.01)).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nisoldipine
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
Nisoldipine mechanism of action
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nisoldipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Dosage forms of Nisoldipine
|Sular||10mg||100 Extended Release Tablet||$145.00|
|Sular||20mg||100 Extended Release Tablet||$172.00|
|Sular||30mg||100 Extended Release Tablet||$195.00|
|Nisoldipine ER||8.5mg||100 Extended Release Tablet||$507.00|
isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nisoldipin
Physicians Total Care, Inc.
Humans and other mammals
Indication of Nisoldipine
For the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
Toxicity of Nisoldipine
Nisoldipine is a dihydropyridine calcium-channel antagonist medication, most often used in a modified release form. It has been prescribed in the United States for less than 10 years. Although the medication has been shown to be safe in common therapeutic use, information on the toxicity and exposure patterns of nisoldipine is sparse, with no robust clinical toxicity data and few case reports found in the medical literature.
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