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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Sular

$599.9130 tablets/34mg
Price with discount in nearest pharmacy. Price may vary.

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Nisoldipine volume of distribution

Volume of distribution was 4.1 ± 2.1 liter/kg and 6.4 ± 2.3 liter/kg (NS) respectively, and systemic clearance was 0.85 ± 0.31 liter/min and 0.49 ± 0.12 liter/ min, respectively (P <0.01). On oral nisoldipine systemic availability was much higher in the patient group (14.7 ± 10.1% vs 3.7 ± 2.1% (P <0.01)).

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What is Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.

Nisoldipine mechanism of action

By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nisoldipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Dosage forms of Nisoldipine

Sular10mg100 Extended Release Tablet$145.00
Sular20mg100 Extended Release Tablet$172.00
Sular30mg100 Extended Release Tablet$195.00
Nisoldipine ER8.5mg100 Extended Release Tablet$507.00

Prescription Generics


International Brands



isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nisoldipin


Physicians Total Care, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Nisoldipine

For the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

Toxicity of Nisoldipine

Nisoldipine is a dihydropyridine calcium-channel antagonist medication, most often used in a modified release form. It has been prescribed in the United States for less than 10 years. Although the medication has been shown to be safe in common therapeutic use, information on the toxicity and exposure patterns of nisoldipine is sparse, with no robust clinical toxicity data and few case reports found in the medical literature.

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