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Price of Nitazoxanide
Alinia 500 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Nitazoxanide volume of distribution
What is Nitazoxanide
Nitazoxanide, also known by the brand name Alinia, is a synthetic nitrothiazolyl-salicylamide derivative and an anti-protozoal agent. It is approved for treatment of infectious diarrhea caused by Cryptosporidium parvum and Giardia lamblia in patients 1 year of age and older. Following oral administration it is rapidly hydrolyzed to its active metabolite, tizoxanide, which is 99% protein bound. Peak concentrations are observed 14 hours after administration. It is excreted in the urine, bile and feces. Untoward effects include abdominal pain, vomiting and diarrhea. (Wikipedia)
Nitazoxanide mechanism of action
The antiprotozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Studies have shown that the PFOR enzyme from Giardia lamblia directly reduces nitazoxanide by transfer of electrons in the absence of ferredoxin. The DNA-derived PFOR protein sequence of Cryptosporidium parvum appears to be similar to that of Giardia lamblia. Interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity.
Dosage forms of Nitazoxanide
|Powder, for suspension||oral||100 mg/5mL|
Romark Laboratories, L.C.
Indication of Nitazoxanide
For the treatment of diarrhea in adults and children caused by the protozoa iGiardia lamblia /i and for the treatment of diarrhea in children caused by the protozoa iCryptosporidium parvum /i.
Toxicity of Nitazoxanide
In acute studies in rodents and dogs, the oral LD sub50 /sub was higher than 10,000 mg/kg. Single oral doses of up to 4000 mg nitazoxanide have been administered to healthy adult volunteers without significant adverse effects.
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