Save up -80% on Nitisinone

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Orfadin

$2,705.8530 capsules/2mg
price without discount in nearest pharmacy. Price may vary.

Claim your free Nitisinone discount card

We offer free Orfadin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Nitisinone every time. What are you waiting for? Claim your prescription drug card now!

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Nitisinone volume of distribution

The capsule and liquid formulations are bioequivalent in both the plasma concentration-time curve and maximum plasma concentration (Cmax).

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Nitisinone

Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. (Wikipedia)

Nitisinone mechanism of action

Nitisinone is a competitive inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme upstream of fumarylacetoacetate hydrolyase (FAH) in the tyrosine catabolic pathway. By inhibiting the normal catabolism of tyrosine in patients with hereditary tyrosinemia type 1 (HT-1), nitisinone prevents the accumulation of the catabolic intermediates maleylacetoacetate and fumarylacetoacetate.

Dosage forms of Nitisinone

FormRouteStrength
Capsuleoral10 mg
Capsuleoral2 mg
Capsuleoral5 mg

Prescription Generics

false

International Brands

Mdk-nitisinone

Synonyms

2-(alpha,alpha,alpha-Trifluoro-2-nitro-P-tuluoyl)-1,3-cyclohexanedione Nitisinona

Manufacturers

Mendelikabs Inc

CAS number

104206-65-7

UNII

K5BN214699

State

solid

Affected organisms

Humans and other mammals

Indication of Nitisinone

Used as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1.

Toxicity of Nitisinone

Side effects include elevated plasma levels of this amino acid, hepatic and liver failure.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Nitisinone on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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