Save up -80% on Nitisinone
Note: this is a drug discount program, not an insurance plan.
2018 Price of Nitisinone
Orfadin 2 mg capsule
* price without discount in nearest pharmacy. Price may vary.
We offer free Nitisinone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Nitisinone every time. What are you waiting for? Claim your prescription drug card now!
Nitisinone volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nitisinone
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. (Wikipedia)
Nitisinone mechanism of action
Nitisinone is a competitive inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme upstream of fumarylacetoacetate hydrolyase (FAH) in the tyrosine catabolic pathway. By inhibiting the normal catabolism of tyrosine in patients with hereditary tyrosinemia type 1 (HT-1), nitisinone prevents the accumulation of the catabolic intermediates maleylacetoacetate and fumarylacetoacetate.
Dosage forms of Nitisinone
Humans and other mammals
Indication of Nitisinone
Used as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1.
Toxicity of Nitisinone
Side effects include elevated plasma levels of this amino acid, hepatic and liver failure.
RX24 Drugs Disclaimer: before buying a Nitisinone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.