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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Nitisinone

Orfadin 2 mg capsule

$61.74

capsule

* price without discount in nearest pharmacy. Price may vary.

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Nitisinone volume of distribution

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What is Nitisinone

Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. (Wikipedia)

Nitisinone mechanism of action

Nitisinone is a competitive inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme upstream of fumarylacetoacetate hydrolyase (FAH) in the tyrosine catabolic pathway. By inhibiting the normal catabolism of tyrosine in patients with hereditary tyrosinemia type 1 (HT-1), nitisinone prevents the accumulation of the catabolic intermediates maleylacetoacetate and fumarylacetoacetate.

Dosage forms of Nitisinone

FormRouteStrength
Capsuleoral10 mg
Capsuleoral2 mg
Capsuleoral5 mg
Prescription Generics

false

International Brands

Mdk-nitisinone

Synonyms

2-(alpha,alpha,alpha-Trifluoro-2-nitro-P-tuluoyl)-1,3-cyclohexanedione Nitisinona

Manufacturers

Mendelikabs Inc

CAS number

104206-65-7

UNII

K5BN214699

State

solid

Affected organisms

Humans and other mammals

Indication of Nitisinone

Used as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1.

Toxicity of Nitisinone

Side effects include elevated plasma levels of this amino acid, hepatic and liver failure.

RX24 Drugs Disclaimer: before buying a Nitisinone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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