Save up -80% on Nitroglycerin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Nitrostat
|$12.40||25 sublingual tablets 0.4 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Nitroglycerin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Nitroglycerin every time. What are you waiting for? Claim your prescription drug card now!
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Nitroglycerin volume of distribution
Volume of distribution 210 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Nitroglycerin
A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium.
Nitroglycerin mechanism of action
Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3′,5′-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Dosage forms of Nitroglycerin
1,2,3-Propanetrioltrinitrate 1,2,3-Propanetriyl nitrate
Humans and other mammals
Indication of Nitroglycerin
For the prevention of angina, decrease in pressure reduces the workload of the heart and helps to relieve heart failure. For EMS providers, typical nitroglycerin indications include chest pain or discomfort associated with angina pectoris or suspected acute myocardial infarction, as well as pulmonary edema with hypertension.
Toxicity of Nitroglycerin
Increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
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