Save up -80% on Nizatidine
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Price of Nizatidine
Axid 150 mg Capsule
* price without discount in nearest pharmacy. Price may vary.
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Nizatidine volume of distribution
* 0.8 to 1.5 L/kg
What is Nizatidine
A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. (PubChem)
Nizatidine mechanism of action
Nizatidine competes with histamine for binding at the H sub2 /sub-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.
Dosage forms of Nizatidine
|Tablet, film coated||oral||75 mg/1|
Humans and other mammals
Indication of Nizatidine
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
Toxicity of Nizatidine
Oral, rat LD sub50 /sub: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.
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