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Price of Norepinephrine
Levophed 1 mg/ml ampul
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Norepinephrine volume of distribution
What is Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. (PubChem)
Norepinephrine mechanism of action
Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it’s activity at the beta-adrenergic receptors.
Dosage forms of Norepinephrine
|Injection, solution, concentrate||intravenous||1 mg/mL|
Humans and other mammals
Indication of Norepinephrine
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Toxicity of Norepinephrine
In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
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