Save up -80% on Norethisterone
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Activella
|$221.78||1 package (28 tablets) 0.1mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Activella coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Norethisterone every time. What are you waiting for? Claim your prescription drug card now!
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Norethisterone volume of distribution
The apparent volume of distribution of norethisterone is 4.4 ± 1.3 L/kg. Following oral administration, the drug serum level time course follows a biphasic pattern. Both phases are characterised by half-lives of 1 – 2 and about 5 -13 hours, respectively.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Norethisterone
Norethisterone (INN, BAN), also known as Norethindrone (USAN), is a synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Norethisterone mechanism of action
Progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.
Dosage forms of Norethisterone
|Tablet, film coated||oral|
|Patch, extended release||transdermal|
Humans and other mammals
Indication of Norethisterone
For the treatment of secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.
Toxicity of Norethisterone
Norethisterone is metabolised mainly in the liver. Approximately 60% of the administered dose is excreted as metabolites in urine and faeces. The toxicity of norethisterone is very low. Reports of teratogenic effects in animals are uncommon.
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