Save up -80% on Obinutuzumab
Note: this is a drug discount program, not an insurance plan.
2018 Price of Obinutuzumab
* price without discount in nearest pharmacy. Price may vary.
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Obinutuzumab volume of distribution
Obinutuzumab has a volume of distribution of about 3.8 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Obinutuzumab
Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).
Obinutuzumab mechanism of action
In contrast to rituximab, which is a classic type I CD20 antibody, obinutuzumab binds to type II CD20 antibodies. This allows obinutuzumab to have a much higher induction of antibody-dependant cytotoxicity and a higher direct cytotoxic effect than the classic CD20 antibodies.
Dosage forms of Obinutuzumab
|Injection, solution, concentrate||intravenous||1000 mg/40mL|
Hoffmann La Roche Limited
Humans and other mammals
Indication of Obinutuzumab
Obinutuzumab is used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia.
Toxicity of Obinutuzumab
The most serious toxicities observed with obinutuzumab are Hepatitis B virus (HBV) reactivation and progressive multifocal leukoencephalopathy (PML). HBV reactivation can occur with all anti-CD20 antibodies and can result in hepatic failure, fulminant hepatitis, and death. PML occurs as a result of JC virus infection and can be fatal as well. Other common but less serious adverse reactions include infusion reactions (pre-treat with glucocorticoids, acetaminophen, and anti-histamine to prevent this), neutropenia, thrombocytopenia, and Tumor Lysis Syndrome (TLS) (pre-treat patients, especially with a high lymphocyte count and/or a high tumor burden, with anti-hyperuricemics and hydration). It is also recommended to NOT administer live virus vaccinations prior to or during obinutuzumab treatment.
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