Save up -80% on Olopatadine

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Pazeo

$186.891 eye dropper (2.5ml) 0.7%
price without discount in nearest pharmacy. Price may vary.

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We offer free Pazeo coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Olopatadine every time. What are you waiting for? Claim your prescription drug card now!

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Olopatadine volume of distribution

The pharmacokinetic parameters (mean +/- SD) for olopatadine following a single dose were: maximum plasma concentration (C(max)) 69.98 +/-20.87 ng/mL, time to reach C(max) (t(max)) 1.02 +/- 0.34 h, elimination half-life (t1/2) 5.87 +/- 4.24 h, area under the plasma-concentration curve (AUC) from time zero to the time of last quantifiable concentration (AUC(last)) 266.00 +/- 143.95 ng.h/mL, AUC from time zero extrapolated to infinity (AUC(infinity)) 283.46 +/- 152.96 ng.h/mL, apparent oral clearance (CL/F) 23.45 +/- 12.59 L/h and apparent volume of distribution after oral administration (V(d)/F) 133.83 +/- 43.07 L. The pharmacokinetic parameters of olopatadine after multiple doses were similar to those after a single dose. In both studies, significantly higher AUC(last), AUC(infinity) and C(max), longer t1/2 (single-dose only) and lower CL/F were observed in female subjects compared with male subjects after both single and multiple dosing. No serious adverse events occurred.

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Total savings $4,735,080

What is Olopatadine

Used to treat allergic conjunctivitis (itching eyes), olopatadine inhibits the release of histamine from mast cells. It is a relatively selective histamine H1 antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells.

Olopatadine mechanism of action

Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Olopatadine is devoid of effects on alpha-adrenergic, dopamine and muscarinic type 1 and 2 receptors.

Dosage forms of Olopatadine

DrugDosageQuantityPrice
Olopatadine0.10%5mL Eyedrops$29.00
Olopatadine0.10%15mL Eyedrops$68.00
Pataday0.20%2.5mL Eyedrop$61.50
Pataday0.20%7.5mL Eyedrop$42.00
Patanase Nasal Spray665mcg30.5g Nasal Spray$302.00
Patanase Nasal Spray665mcg91.5g Nasal Spray$876.00
Patanol0.10%5mL Eyedrops$22.90
Patanol0.10%10mL Eyedrops$36.20

Prescription Generics

false

International Brands

Act Olopatadine 0.1%

Synonyms

Olopatadin Olopatadina

Manufacturers

Actavis Pharma Company

CAS number

113806-05-6

UNII

D27V6190PM

State

solid

Affected organisms

Humans and other mammals

Indication of Olopatadine

For the treatment of ocular itching associated with allergic conjunctivitis.

Toxicity of Olopatadine

The acute toxicity of olopatadine hydrochloride has been investigated in mice, rats and dogs. Mice and rats demonstrated that olopatadine hydrochloride was not an acute toxicity hazard with oral LD50 values greater than 1150 mg/kg and 3870 mg/kg for mice and rats, respectively.

Subchronic and chronic oral toxicity studies in rats and dogs demonstrated that the liver and kidney were target organs for olopatadine hydrochloride toxicity. In rats, ophthalmology and hematology parameters were unaffected following chronic administration of olopatadine hydrochloride. In chronic dog studies, ophthalmology, hematology, blood chemistry and organ weight parameters were unaffected by olopatadine hydrochloride administration.

A one-month topical ocular study was conducted with 0.1% (4 times a day) or 0.2% Olopatadine hydrochloride (4 and 5 times a day) Ophthalmic Solution in New Zealand White (NZW) rabbits. No signs of pharmacotoxicity were observed. Slit-lamp and indirect ocular evaluations and pachymetry revealed no treatment-related findings. Clinical pathology data and histopathology were unremarkable.

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What is Patanase?

Patanase is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can cause symptoms of sneezing, itching, watery eyes and runny nose.

Patanase Nasal Spray is used to treat symptoms such as congestion, sneezing, and runny nose caused by seasonal allergies. Patanase is intended for adults and children who are at least 6 years old.

Before using Patanase, tell your doctor if you have any non-allergic conditions that affect the inside of your nose, such as a deviated septum.

Patanase may impair your thinking or reaction. Be careful if you are driving or doing everything that requires your attention. Drinking alcohol may increase some side effects of Patanase. Call your doctor if your symptoms do not improve, or if they worsen with this medicine.