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Price of Olsalazine
Dipentum 250 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Olsalazine volume of distribution
What is Olsalazine
Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. Olsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Mesalamine works as an anti-inflammatory agent in treating inflammatory diseases of the intestines.
Olsalazine mechanism of action
Orally administered olsalazine is converted to mesalamine which is thought to be the therapeutically active agent in the treatment of ulcerative colitis. The mechanism of action of mesalamine (and sulfasalazine) is unknown, but appears to be topical rather than systemic. Mucosal production of arachidonic acid (AA) metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes (LTs) and hydroxyelcosatetraenoic acids (HETEs) is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin (PG) production in the colon.
Dosage forms of Olsalazine
|Capsule, gelatin coated||oral||250 mg/1|
Alaven Pharmaceutical LLC
Humans and other mammals
Indication of Olsalazine
For the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.
Toxicity of Olsalazine
Maximum single oral doses of 5g/kg in mice and rats and 2 g/kg in dogs were not lethal.
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