Save up -80% on Omacetaxine mepesuccinate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Synribo
|$8,258||1 vial (8ml) 3.5mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Omacetaxine mepesuccinate coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Omacetaxine mepesuccinate every time. What are you waiting for? Claim your prescription drug card now!
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Omacetaxine mepesuccinate volume of distribution
Homoharringtonine has a steady state Vd of 141 93.4 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Omacetaxine mepesuccinate
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Omacetaxine mepesuccinate mechanism of action
Homoharringtonine inhibits protein synthesis by not directly binding to Bcr-Abl. It binds to the A-site cleft in the large ribosomal subunit, which affects chain elongation and prevents protein synthesis.
Dosage forms of Omacetaxine mepesuccinate
|Injection, powder, lyophilized, for solution||subcutaneous||3.5 mg/mL|
( )-homoharringtonine (2’R,3S,4S,5R)-( )-homoharringtonine
Humans and other mammals
Indication of Omacetaxine mepesuccinate
Used in patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Toxicity of Omacetaxine mepesuccinate
The most severe adverse effects after homoharringtonine administration are myelosuppression, bleeding, hyperglycemia, and fetal harm.
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