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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Omacetaxine mepesuccinate

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Omacetaxine mepesuccinate volume of distribution

Homoharringtonine has a steady state Vd of 141 93.4 L.

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What is Omacetaxine mepesuccinate

Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.

Omacetaxine mepesuccinate mechanism of action

Homoharringtonine inhibits protein synthesis by not directly binding to Bcr-Abl. It binds to the A-site cleft in the large ribosomal subunit, which affects chain elongation and prevents protein synthesis.

Dosage forms of Omacetaxine mepesuccinate

FormRouteStrength
Injection, powder, lyophilized, for solutionsubcutaneous3.5 mg/mL
Prescription Generics

false

International Brands

Synribo

Synonyms

( )-homoharringtonine (2’R,3S,4S,5R)-( )-homoharringtonine

Manufacturers

Cephalon, Inc.

CAS number

26833-87-4

UNII

6FG8041S5B

State

solid

Affected organisms

Humans and other mammals

Indication of Omacetaxine mepesuccinate

Used in patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.

Toxicity of Omacetaxine mepesuccinate

The most severe adverse effects after homoharringtonine administration are myelosuppression, bleeding, hyperglycemia, and fetal harm.

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