Save up -80% on Omacetaxine mepesuccinate
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2018 Price of Omacetaxine mepesuccinate
* price without discount in nearest pharmacy. Price may vary.
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Omacetaxine mepesuccinate volume of distribution
Homoharringtonine has a steady state Vd of 141 93.4 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Omacetaxine mepesuccinate
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Omacetaxine mepesuccinate mechanism of action
Homoharringtonine inhibits protein synthesis by not directly binding to Bcr-Abl. It binds to the A-site cleft in the large ribosomal subunit, which affects chain elongation and prevents protein synthesis.
Dosage forms of Omacetaxine mepesuccinate
|Injection, powder, lyophilized, for solution||subcutaneous||3.5 mg/mL|
( )-homoharringtonine (2’R,3S,4S,5R)-( )-homoharringtonine
Humans and other mammals
Indication of Omacetaxine mepesuccinate
Used in patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Toxicity of Omacetaxine mepesuccinate
The most severe adverse effects after homoharringtonine administration are myelosuppression, bleeding, hyperglycemia, and fetal harm.
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