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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zofran

$7.5310 orally disintegrating tabs/4 mg
Price with discount in nearest pharmacy. Price may vary.

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Ondansetron volume of distribution

Ondansetron is widely distributed (volume of distribution approximately 160L) and binds moderately (70 to 76%) to plasma proteins; the elimination half-life averages approximately 3.8 +/- 1 hours.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Ondansetron

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Ondansetron mechanism of action

Ondansetron is a selective serotonin 5-HTsub3/sub receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HTsub3/sub receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HTsub3/sub receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

Dosage forms of Ondansetron

Injectionintramuscular; intravenous2 mg/mL
Injection, solutionintramuscular2 mg/mL
Injection, solutionintramuscular; intravenous4 mg/2mL

Prescription Generics


International Brands

Act Ondansetron


Zofran odt


Actavis Pharma Company

CAS number






Affected organisms

Humans and other mammals

Indication of Ondansetron

For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, postoperation, and radiation. Also used for the treatment of postoperative nausea and vomiting.

Toxicity of Ondansetron

Low blood pressure and fainting, sudden blindness, severe constipation

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