Save up -80% on Oprelvekin
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2018 Price of Oprelvekin
Neumega 5 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Oprelvekin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Oprelvekin
Oprelvekin, the active ingredient in Neumega/ is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo. The primary hematopoietic activity of Neumega/ is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega/ has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega/ improved platelet nadirs and accelerated platelet recoveries compared to controls. In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines.
Oprelvekin mechanism of action
Oprelvekin binds to the interleukin 11 receptor which leads to a cascade of signal transduction events. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
Dosage forms of Oprelvekin
Adipogenesis inhibitory factor AGIF
Wyeth Bio Pharma Division Of Wyeth Pharmaceuticals Inc., A Subsidiary Of Pfizer Inc.
Humans and other mammals
Indication of Oprelvekin
Increases reduced platelet levels due to chemotherapy
Toxicity of Oprelvekin
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