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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Oprelvekin

Neumega 5 mg vial

$352.9

vial

* price without discount in nearest pharmacy. Price may vary.

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Oprelvekin volume of distribution

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What is Oprelvekin

Oprelvekin, the active ingredient in Neumega/ is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo. The primary hematopoietic activity of Neumega/ is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega/ has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega/ improved platelet nadirs and accelerated platelet recoveries compared to controls. In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines.

Oprelvekin mechanism of action

Oprelvekin binds to the interleukin 11 receptor which leads to a cascade of signal transduction events. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

Dosage forms of Oprelvekin

FormRouteStrength
Kit
Prescription Generics

false

International Brands

Neumega

Synonyms

Adipogenesis inhibitory factor AGIF

Manufacturers

Wyeth Bio Pharma Division Of Wyeth Pharmaceuticals Inc., A Subsidiary Of Pfizer Inc.

CAS number

145941-26-0

UNII

HM5641GA6F

State

liquid

Affected organisms

Humans and other mammals

Indication of Oprelvekin

Increases reduced platelet levels due to chemotherapy

Toxicity of Oprelvekin

RX24 Drugs Disclaimer: before buying a Oprelvekin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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