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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Orphenadrine

Orphenadrine comp tablet



* price without discount in nearest pharmacy. Price may vary.

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Orphenadrine volume of distribution

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What is Orphenadrine

A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.

Orphenadrine mechanism of action

Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.

Dosage forms of Orphenadrine

Tabletoral50 mg
Liquidintramuscular; intravenous30 mg
Prescription Generics


International Brands

Disipal Tab 50mg


2-(phenyl-o-tolylmethoxy)ethyldimethylamine 2-methyldiphenhydramine


3 M Pharmaceuticals, A Division Of 3 M Canada Company

CAS number






Affected organisms

Humans and other mammals

Indication of Orphenadrine

Indicated for the treatment of Parkinson‘s disease.

Toxicity of Orphenadrine

Oral, mouse LD sub50 /sub = 100 mg/kg; oral, rat LD sub50 /sub = 255 mg/kg

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