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Price of Oseltamivir
Tamiflu 30 mg gel capsule
* price without discount in nearest pharmacy. Price may vary.
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Oseltamivir volume of distribution
* 23 to 26 L
What is Oseltamivir
An acetamido cyclohexene that is a structural homolog of sialic acid and inhibits neuraminidase. (PubChem)
Oseltamivir mechanism of action
Oseltamivir is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate. The proposed mechanism of action of oseltamivir is inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.
Dosage forms of Oseltamivir
|Capsule, hard||Oral use||30 mg|
|Capsule, hard||Oral use||45 mg|
|Capsule, hard||Oral use||75 mg|
1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha,4beta,5alpha))-
Natco Pharma (Canada) Inc
Indication of Oseltamivir
Oseltamivir (Tamiflu) is for the treatment of uncomplicated acute illness due to influenza infection in patients 1 year and older who have been symptomatic for no more than 2 days. It is also used for the prophylaxis of influenza in adult patients and adolescents 13 years and older.
Toxicity of Oseltamivir
At present, there has been no experience with overdose. Single doses of up to 1000 mg of oseltamivir have been associated with nausea and/or vomiting. Mean LD (intravenous, mouse) = 100 mg/kg.
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