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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Oxaliplatin

Oxaliplatin 50 mg vial

$825.0

vial

* price without discount in nearest pharmacy. Price may vary.

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Oxaliplatin volume of distribution

* 440 L (single 2-hour IV infusion at dose of 85 mg/m^2) At the end of a 2-hour infusion of oxaliplatin, approximately 15% of the administered platinum is present in the systemic circulation. The remaining 85% is rapidly distributed into tissues or eliminated in the urine.

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What is Oxaliplatin

Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. It is typically administered in combination with fluorouracil and leucovorin in a combination known as Folfox for the treatment of colorectal cancer. Compared to cisplatin the two amine groups are replaced by cyclohexyldiamine for improved antitumour activity. The chlorine ligands are replaced by the oxalato bidentate derived from oxalic acid in order to improve water solubility. Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin reg;.

Oxaliplatin mechanism of action

Oxaliplatin undergoes nonenzymatic conversion to active derivatives via displacement of the labile oxalate ligand. Several transient reactive species are formed, including monoaquo and diaquo DACH platinum, which covalently bind with macromolecules. After activation, oxaliplatin binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and transcription. Cytotoxicity is cell-cycle nonspecific.

Dosage forms of Oxaliplatin

FormRouteStrength
Injection, solution, concentrateintravenous5 mg/mL
Solutionintravenous5 mg
Injection, powder, lyophilized, for solutionintravenous100 mg/20mL
Prescription Generics

false

International Brands

Act Oxaliplatin

Synonyms

Diaminocyclohexane Oxalatoplatinum L-OHP

Manufacturers

Actavis Pharma Company

CAS number

61825-94-3

UNII

04ZR38536J

State

solid

Affected organisms

Humans and other mammals

Indication of Oxaliplatin

Used in combination with infusional 5-FU/LV, is indicated for the treatment of advanced carcinoma of the colon or rectum and for adjuvant treatment of stage III colon cancer patients who have undergone complete resection of the primary tumor.

Toxicity of Oxaliplatin

There have been five cases of oxaliplatin overdose reported. One patient received two 130 mg/m2 doses of oxaliplatin (cumulative dose of 260 mg/m sup2 /sup) within a 24-hour period. The patient experienced Grade 4 thrombocytopenia ( 25,000/mm sup3 /sup) without any bleeding, which resolved. Two other patients were mistakenly administered oxaliplatin instead of carboplatin. One patient received a total oxaliplatin dose of 500 mg and the other received 650 mg. The first patient experienced dyspnea, wheezing, paresthesia, profuse vomiting and chest pain on the day of administration. She developed respiratory failure and severe bradycardia, and subsequently did not respond to resuscitation efforts. The other patient also experienced dyspnea, wheezing, paresthesia, and vomiting. Most common adverse reactions (incidence . 40%) were peripheral sensory neuropathy, neutropenia, thrombocytopenia, anemia, nausea, increase in transaminases and alkaline phosphatase, diarrhea, emesis, fatigue and stomatitis.

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