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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Oxtriphylline

Pms-Oxtriphylline 20 mg/ml Elixir

$0.02

ml

* price without discount in nearest pharmacy. Price may vary.

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Oxtriphylline volume of distribution

Theophylline has an apparent volume of distribution of 0.3 .7 L/kg in children and adults, and the Vd is about twice that of an adult in premature infants.

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What is Oxtriphylline

Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.

Oxtriphylline mechanism of action

Oxtriphylline is a choline salt of theophylline. After ingestion, theophylline is released from oxytriphylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.

Dosage forms of Oxtriphylline

FormRouteStrength
Tabletoral100 mg
Tabletoral200 mg
Tabletoral300 mg
Prescription Generics

true

International Brands

Apo Oxtriphylline Tab 100mg

Synonyms

Choline theophyllinate Choline theophylline

Manufacturers

Apotex Inc

CAS number

4499-40-5

UNII

3K045XR58X

State

solid

Affected organisms

Humans and other mammals

Indication of Oxtriphylline

Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema.

Toxicity of Oxtriphylline

Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).

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