Save up -80% on Oxycodone
Note: this is a drug discount program, not an insurance plan.
2018 Price of Oxycodone
Oxycodone hcl 20 mg tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Oxycodone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Oxycodone every time. What are you waiting for? Claim your prescription drug card now!
Oxycodone volume of distribution
* 2.6 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Oxycodone
Oxycodone is a semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. An extended-release (ER) form of oxycodone (Xtampza ER) was approved for the management of daily, around-the-clock pain management in April, 2016.
Oxycodone mechanism of action
Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Dosage forms of Oxycodone
|Tablet (extended-release)||oral||5 mg|
|Tablet (extended-release)||oral||10.0 mg|
|Tablet (extended-release)||oral||20.0 mg|
Act Oxycodone CR
Actavis Pharma Company
Humans and other mammals
Indication of Oxycodone
For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.
Toxicity of Oxycodone
Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.
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