Save up -80% on Oxymorphone
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2018 Price of Oxymorphone
Opana ER 5 mg 12 Hour tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Oxymorphone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Oxymorphone every time. What are you waiting for? Claim your prescription drug card now!
Oxymorphone volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Oxymorphone
An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
Oxymorphone mechanism of action
Oxymorphone interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. Also, it has been shown that oxymorphone binds to and inhibits GABA inhibitory interneurons via mu-receptors. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.
Dosage forms of Oxymorphone
|Liquid||intramuscular; intravenous; subcutaneous||1.5 mg|
|Injection||intramuscular; intravenous; subcutaneous||1 mg/mL|
Numorphan Injection 1.5mg/ml
Bristol Myers Squibb Canada
Humans and other mammals
Indication of Oxymorphone
For the treatment of moderate-to-severe pain.
Toxicity of Oxymorphone
Oxymorphone overdosage is characterized by respiratory depression, extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In a severe case of overdose, apnea, circulatory collapse, cardiac arrest, and death may occur. Intravenous mouse LD sub50 /sub is 172 mg/kg.
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