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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Oxymorphone

Opana ER 5 mg 12 Hour tablet



* price without discount in nearest pharmacy. Price may vary.

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Oxymorphone volume of distribution

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What is Oxymorphone

An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)

Oxymorphone mechanism of action

Oxymorphone interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. Also, it has been shown that oxymorphone binds to and inhibits GABA inhibitory interneurons via mu-receptors. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.

Dosage forms of Oxymorphone

Liquidintramuscular; intravenous; subcutaneous1.5 mg
Suppositoryrectal5 mg
Injectionintramuscular; intravenous; subcutaneous1 mg/mL
Prescription Generics


International Brands

Numorphan Injection 1.5mg/ml


14-Hydroxydihydromorphinone Dihydrohydroxymorphinone


Bristol Myers Squibb Canada

CAS number






Affected organisms

Humans and other mammals

Indication of Oxymorphone

For the treatment of moderate-to-severe pain.

Toxicity of Oxymorphone

Oxymorphone overdosage is characterized by respiratory depression, extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In a severe case of overdose, apnea, circulatory collapse, cardiac arrest, and death may occur. Intravenous mouse LD sub50 /sub is 172 mg/kg.

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