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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Oxytocin

Pitocin 10 unit/ml vial

$1.6

ml

* price without discount in nearest pharmacy. Price may vary.

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Oxytocin volume of distribution

Distributes throughout the extracellular fluid and crosses the placenta. It is probable that it also distributes into milk in small amounts.

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What is Oxytocin

Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity.

Oxytocin mechanism of action

Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin’s light chain kinase.. Oxytocin has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

Dosage forms of Oxytocin

FormRouteStrength
Injectionintramuscular; intravenous10[USP’U]/mL
Injection, solutionintramuscular; intravenous10[USP’U]/mL
Injection, solutionintravenous10[USP’U]/1000mL
Prescription Generics

false

International Brands

Oxytocin

Synonyms

Pitocin Syntocinon

Manufacturers

Fresenius Kabi USA, LLC

CAS number

50-56-6

UNII

1JQS135EYN

State

liquid

Affected organisms

Humans and other mammals

Indication of Oxytocin

Used for labor induction, augmentation of labor, postpartum abbreviation of third stage of labor, postpartum control of uterine bleeding, termination of pregnancy and for the evaluation of fetal respiratory capability. Oxytocin cannot be used for elective induction of labor, there must be a clear medical requirement.

Toxicity of Oxytocin

Oxytocin can produce a severe water intoxication due to its antidiuretic effect. Prolonged IV infusions of more 40milliunits/min are usually the cause. Severe water intoxication with convulsions, coma, and death can occur. Some neonatal seizures have also been reported. Consider potential for water intoxication, particularly when administered by IV infusion and patient is receiving oral fluids. ; Uterine effects: High doses or hypersensitivity to oxytocin may cause uterine hypertonicity, spasm, tetanic contraction, or rupture of the uterus. There have also been reported allergic and anaphylactic reactions to oxytocin but they were rarely fatal.

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