Save up -80% on Palbociclib

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Ibrance

$11,2211 bottle (21 capsules) 75 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Ibrance coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Palbociclib every time. What are you waiting for? Claim your prescription drug card now!

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Palbociclib volume of distribution

The mean apparent distribution of palbociclib is 2583 L, suggesting that palbociclib penetrates extensively into peripheral tissues.

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Palbociclib

Palbociclib is an oral, reversible, selective, small-molecule inhibitor of CDK4 and CDK6 indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. CDK4 and CDK6 along with their regulatory partner cyclin D1 play a key role in regulating the G1- to S-phase cell-cycle transition via regulation of phosphorylation of the retinoblastoma (Rb) protein. Inhibition of these proteins leads to reduced phosphorylation of Rb, inhibition of downstream signalling, and increased tumor growth arrest. Palbociclib received an accelerated approval from the Food and Drug Administration on February 3, 2015.

Palbociclib mechanism of action

Palbociclib is an oral, reversible, selective, small-molecule inhibitor of CDK4 and CDK6. CDK4 and CDK6 along with their regulatory partner cyclin D1 play a key role in regulating the G1- to S-phase cell-cycle transition via regulation of phosphorylation of the retinoblastoma (Rb) protein.

Dosage forms of Palbociclib

DrugDosageQuantityPrice
Ibrance75mg21 capsules$11,221
Ibrance100mg21 capsules$11,524
Ibrance125mg21 capsules$11,526

Prescription Generics

false

International Brands

Ibrance

Synonyms

6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one

Manufacturers

Pfizer Canada Inc

CAS number

571190-30-2

UNII

G9ZF61LE7G

State

solid

Affected organisms

Indication of Palbociclib

Palbociclib is indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. This indication is approved under accelerated approval based on progression-free survival (PFS). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

Toxicity of Palbociclib

In the large clinical trials, adverse events were common and led to dose reductions in one-third of patients and discontinuation in 8%. Publications on the efficacy and safety of palbociclib have not mentioned serum ALT elevations or hepatotoxicity. There have been no publications or case reports of clinically apparent liver injury attributable to palbociclib; however, there has been only limited, general clinical use of this kinase inhibitor and serum enzyme elevations can occur during treatment.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Palbociclib on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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