Save up -80% on Palivizumab
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Price of Palivizumab
100 mg/mL intramuscular solution
* price without discount in nearest pharmacy. Price may vary.
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Palivizumab volume of distribution
What is Palivizumab
Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Synagis is a composite of human (95%) and murine (5%) antibody sequences. The human heavy chain sequence was derived from the constant domains of human IgG1 and the variable framework regions of the VH genes Cor (1) and Cess (2). The human lightchain sequence was derived from the constant domain of Ck and the variable framework regions of the VL gene K104 withJk-4. Palivizumab is expressed from a stable murine (mouse) myeloma cell line (NS0). Palivizumab is composed of to heavy chains (50.6 kDa each) and two light chains (27.6 kDa each), contains 1-2% carbohydrate by weight and has a molecular weight of 147.7 kDa +/- 1 kDa (MALDI-TOF)
Palivizumab mechanism of action
Palivizumab binds to the fusion glycoprotein of RSV. This prevents its binding and uptake by host cellular receptors.
Dosage forms of Palivizumab
|Injection, solution||intramuscular||100 mg/mL|
|Injection, solution||intramuscular||50 mg/.5mL|
|Powder and solvent for solution for injection||Intramuscular use||100 mg|
Indication of Palivizumab
For prophylaxis of respiratory diseases casued by respiratory syncytial virus.
Toxicity of Palivizumab
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